Julia severely damages her face. At first, Sean refuses to operate on her, still bitter that she recently got breast implants from a rival plastic surgeon.
As Sean reluctantly celebrates his 40th birthday, Christian urges him to take advantage of some of the youth-preserving treatments available at the clinic.
Sean suffers uncontrollable spasms in his hands. After he nicks a patient's major neck artery during a routine cyst lancing, Sean stops performing surgeries.
Christian and Sean agree to rehabilitate a stalwart, optimistic Somali woman, Manya Mabika, who was genitally mutilated as a girl in her home country.
Sean and Julia discover that Annie is entering puberty already. While struggling with their own issues regarding aging, they try to help their daughter understand what's happening.
Sean is broadsided by another car and rushed to the hospital. He was saved from major injury, but his view of life has changed.
While Julia enjoys socializing with "life coach" Ava Moore, Matt also makes progress working through his feelings with the alluring Ava.
Former patient Bobbi Broderick stalks the doctors, threatens to sue, drives away customers, and tries to get a reporter to do an exposé on what she perceives as their malpractice.
The doctors fear a homeless prostitute wants pro bono surgery for scars on her wrists. But she tells them she's being deified because her injuries resemble the stigmata.
Sean learns that Christian is Matt's biological father due to a premarital tryst with Julia. He ejects Julia from their house and demands his partnership with Christian be dissolved.
Having tenuously reconciled and agreed to continue their partnership, Sean and Christian consult with an exuberant newspaper journalist, Ike Connors, who wants breast implants for himself.
While the doctors work with an expert ocularist to create and implant artificial eyes for a beautiful blind woman, Natasha Charles, Christian finds himself drawn to her.
Sean and Christian learn that their old associate, Merrill Bobolit, is performing cheap, illegal cosmetic surgery on poverty-stricken people.
Sean and Christian reluctantly accept the case of Trudy Nye, who wants her nose fixed.
Sean has been operating pro bono on victims of The Carver, a serial rapist. Sean attracts the attention of a newswoman, but his television exposure has terrible consequences.
Celebrity Joan Rivers (herself) consults with the doctors. However, what she requests astonishes Sean and Christian.